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LCHS Grad, Heather Palmerini, Ph.D. Speaking to AP Biology and Anatomy & Physiology Students Friday Jan. 28th 2010
Below is a figure demonstrating the role of a cohesin protein; an important protein in meiosis. Meiosis is an important research area relevant to issues such as infertility and chromosomal abnormalities. Heather Palmerini Ph.D, a LCHS Grad (1996) will speak to my morning classes on Friday 1/29 about her thesis project in this field. Heather recently finished her Ph.D. in Cellular Molecular, and Developmental Biology.
Localization of meiotic cohesin complexes during mammalian meiotic divisions. Rec8-containing meiotic cohesin is localized along the chromosomal axes between sister chromatids, including the centromere regions, the arm regions both proximal and distal to chiasmata at metaphase I. At this stage, the arm cohesion distal to chiasmata is responsible for uniting homologous chromosomes together, and the resolution of them triggers separation of the homologs at anaphase I. Rec8 is released from the arm regions concomitantly with the separation of homologs. In metaphase II, Rec8-containing meiotic cohesin is localized at centromere regions at which sister chromatid cohesion is maintained. Release of Rec8 from the centromere regions coincides with the separation of sister chromatids in anaphase II.
Below is an image of all the stages of mitosis. Mitosis is one type of cell division. It is important for scientists to understand mitosis because when cell division is out of control, cancer can result.
